Calculation of Topological Descriptor For Qsar Study on Carbonic Anhydrase Inhibitor-I (Ca-I)

Dr. Sarla Biloniya, Dr. R.G. Verma, Dr. Aruna Solanki

Abstract


In this paper we report that QSAR study on carbonic anhydrase inhibitor-I (CA-I) using some topological descriptor on substituted aromatic sulphonamide. We restrict ourselves on topological indices viz. Balabon index (J) Randic connectivity  based index (χ) Winner index (W), JHETZ, JHETM, JHETV, JHETP, BAC.


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Rouvray, D. H. New Scientist 1993a, May 29, 35-38.

Hansch, C., Fujita, T. J. Am. Chem. Soc. 1964. 86, 1616.

Khadikar, P. V.; Clare, B. W.; Balaban, A. T.; Supuran, C. T.; Agrawal, V. K.; Singh, J.; Joshi, A.K.; Lakhwani, M. Romania Rev 2005.

Singh, J.; Lakhwani, M.; Khadikar, P. V.; Agrawal, V. K.; Balaban, A. T.; Clare, B.W.;

Supuran, C. T. Romania Rev 2006.

S. Parkkila in W. R. Chegwidden, N. D. Carter, Edwards, Y.H. (eds.), Carbonic Anhydrase New Horizons: An Overview of the Distribution and Function of Carbonic Anhydrase in Mammals, Birkhauser Verlag Basel, Switzerland, 2000, pp 80-93.

B. Ulmasov, A. Waheed, G. N. Shah, J. H. Grubb, W. S. Sly, C. K. Tu, D. N. Silverman, Proc. Natl. Acad. Sci.USA, 2000, 97, 14212.

Supuran, C. T.; Scozzafava, A.; Casini, A. Med. Res. Rev. 2003, 23, 146.

Casini, A.; Scozzafava, A.; Mincione, F.; Menabuoni, L.; Supuran, C. T. J. Enz. Inh. Med. Chem. 2002, 17, 333.

Casini, A.; Mincione, F.; Vullo, D.; Menabuoni, L.; Scozzafava, A.; Supuran, C. T. J. Enz. Inh. Med. Chem. 2002, 17, 9.

Kim, C.-Y.; Whittington, D. A.; Chang, J. S.; Liao, J.; May, J. A.; Christianson, D. W. J. Med. Chem. 2002, 45, 888.

Winum, J.-Y.; Scozzafava, A.; Montero, J.-L. ;.; Supuran, C. T. Med. Res. Rev. 2005, 25, 186.

Cecchi, A.; Winum, J.-Y.; Innocenti, A.; Vullo, D.; Montero, J.-L.; Scozzafava, A.; Supuran, C. T. Bioorg. Med. Chem. Lett. 2004, 14, 5775.

Franchi, M.; Vullo, D.; Gallori, E.; Pastorek, J.; Russo, A.; Scozzafava, A.; Pastorekova, S.; Supuran, C. T. J. Enz. Inh. Med. Chem. 2003, 18, 333.

Mnicione, F., Menabuoni L, Supuran CT, Convey, J. Eds. CRC Press, Boca Raton (FL) , 2004, pp. 243-254.

Clare BW, Supuran CT Convey, J. Eds. CRC Press, Boca Raton (FL) , 2004 pp 260-271.

S. Lindskog, Pharmacol. Ther., 1997, 74, 1.

D. W. Christianson, C. A. Fierke, Acc. Chem. Res., 1996, 29, 331.

S. Lindskog, D. N. Silverman, in W. R. Chegwidden, N. D. Carter, Y. H. Edwards (eds.), Carbonic Anhydrase New Horizons: An Overview of the Distribution and Function of Carbonic Anhydrase in Mammals, Birkhauser Verlag Basel, Switzerland, 2000, pp 175-95.

A. E. Eriksson, T. A. Jones, A. Liljas, Proteins: Struct. Funct. Genet., 1988, 4, 274.


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